Expression of Bcl-2, Bax, and p53 in high-grade prostatic intraepithelial neoplasia and localized prostate cancer: relationship with apoptosis and proliferation.

@article{Johnson1998ExpressionOB,
  title={Expression of Bcl-2, Bax, and p53 in high-grade prostatic intraepithelial neoplasia and localized prostate cancer: relationship with apoptosis and proliferation.},
  author={Mark I Johnson and Mary C. Robinson and Colin Marsh and Craig N. Robson and Durwood E. Neal and Freddie Hamdy},
  journal={The Prostate},
  year={1998},
  volume={37 4},
  pages={223-9}
}
BACKGROUND Apoptosis-regulating genes have been shown to be important in the biology of prostate cancer. The aim of this study was to examine and correlate the expression of the apoptosis-regulating genes bcl-2, bax, and p53 with the frequency of apoptosis and rate of proliferation in benign prostatic epithelium (BP), prostate cancer, and high-grade prostatic intraepithelial neoplasia (HGPIN), which is currently considered the most likely precursor of prostate cancer. METHODS Forty-four… CONTINUE READING
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