Expression of BRG1, a human SWI/SNF component, affects the organisation of actin filaments through the RhoA signalling pathway.

@article{Asp2002ExpressionOB,
  title={Expression of BRG1, a human SWI/SNF component, affects the organisation of actin filaments through the RhoA signalling pathway.},
  author={Patrik Asp and Margareta Wihlborg and Mattias Karl{\'e}n and A K Ostlund Farrants},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 13},
  pages={2735-46}
}
The human BRG1 (brahma-related gene 1) protein is a component of the SWI/SNF family of the ATP-dependent chromatin remodelling complexes. We show here that expression of the BRG1 protein, but not of an ATPase-deficient BRG1 protein, in BRG1-deficient SW13 cells alters the organisation of actin filaments. BRG1 expression induces the formation of thick actin filament bundles resembling stress-fibres, structures that are rarely seen in native SW13 cells. BRG1 expression does not influence the… CONTINUE READING

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