Expression of BPI (bactericidal/permeability-increasing protein) in human mucosal epithelia.

@article{Levy2003ExpressionOB,
  title={Expression of BPI (bactericidal/permeability-increasing protein) in human mucosal epithelia.},
  author={Ofer Levy and Geraldine Canny and Charles Nicholas Serhan and Sean P Colgan},
  journal={Biochemical Society transactions},
  year={2003},
  volume={31 Pt 4},
  pages={
          795-800
        }
}
Among the antimicrobial proteins and peptides of humans is the cationic 55 kDa bactericidal/permeability-increasing protein (BPI), which possesses antibacterial, endotoxin-neutralizing and opsonic activity against Gram-negative bacteria. Although identified originally as an abundant constituent of neutrophil granules, we have recently identified functional expression of BPI by human mucosal epithelia. BPI expression was markedly up-regulated by exposure of epithelia to lipoxins, endogenous anti… CONTINUE READING

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