Expression of BNIP3 correlates with hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines.

@article{Shaida2008ExpressionOB,
  title={Expression of BNIP3 correlates with hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines.},
  author={Nadeem Shaida and Rosalind J Launchbury and Jane Letitia Boddy and Catherine M. Jones and Leticia Campo and Helen Turley and Suresh Kanga and Alison H Banham and Peter R. Malone and Adrian L. Harris and Stephen B. Fox},
  journal={The Prostate},
  year={2008},
  volume={68 3},
  pages={
          336-43
        }
}
BACKGROUND BNIP3 is a hypoxia-induced protein involved in cell death and survival but its role in human tumors is unclear. This study investigated the role of BNIP3 in prostate cancer. METHODS The expression of BNIP3, the androgen receptor (AR), hypoxia inducible factor (HIF)-1alpha, HIF-2alpha and the hypoxia regulated gene GLUT1 were assessed in tissue microarrays constructed from 149 radical prostatectomy specimens. Statistics compared expression of these factors between each other… CONTINUE READING

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