Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome.

@article{Novak2004ExpressionOB,
  title={Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome.},
  author={Anne J. Novak and Deanna M. Grote and Mary J. Stenson and Steven C. Ziesmer and Thomas E Witzig and Thomas Matthew Habermann and Brandon Harder and Kay M. Ristow and Richard J. Bram and Diane F. Jelinek and Jane A. Gross and Stephen M Ansell},
  journal={Blood},
  year={2004},
  volume={104 8},
  pages={2247-53}
}
BLyS, recently shown to be critical for survival of normal B cells, has been found to be elevated in a number of immune disease models. A role for BLyS in the survival of malignant B cells has also been revealed and we therefore sought to identify a role for BLyS and its receptors in non-Hodgkin lymphoma (NHL). We found that tumor cells from all NHL histologic subtypes expressed one or more of 3 known receptors (BCMA, TACI, and BAFF-R) for BLyS; however, the pattern of expression was variable… CONTINUE READING
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, establishing TACI as an inhibitory BLyS receptor

  • AJ Novak, Darce, BK Arendt
  • Immunity
  • 2003

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