Expression of BCL-2 proto-oncogene in adult acute lymphoblastic leukemia.

  title={Expression of BCL-2 proto-oncogene in adult acute lymphoblastic leukemia.},
  author={Lydia Campos and Odile Sabido and Catherine J Sebban and Christiane Charrin and M. F. Bertheas and Denis Fi{\`e}re and Denis Guyotat},
  volume={10 3},
The products of the BCL-2 gene prolong survival of lymphohematopoietic cells by inhibition of programmed cell death. We studied bcl-2 protein expression in a series of 43 adult acute lymphoblastic leukemia (ALL) at diagnosis, using a specific monoclonal antibody and flow cytometry. All samples expressed bcl-2 with a mean percentage of positive cells of 77.9. The level of bcl-2 in positive cells expressed as mean equivalent of soluble fluorescence (MESF) was highly variable ranging from 5 x 10(3… CONTINUE READING


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