Expression of B7 costimulator molecules on mouse dendritic cells.

@article{Inaba1995ExpressionOB,
  title={Expression of B7 costimulator molecules on mouse dendritic cells.},
  author={Kayo Inaba and Muneo Inaba and M D Witmer-Pack and K Hatchcock and Richard Hodes and Ralph Marvin Steinman},
  journal={Advances in experimental medicine and biology},
  year={1995},
  volume={378},
  pages={
          65-70
        }
}
Dendritic cells express most known accessory molecules [ICAM's, LFA's, B7's, and CD40] for binding and stimulating T cells. B7 is the most abundant of these, and B7-2 very much predominates relative to B7-1. B7 expression is regulated, not by LPS, but by some signal [s] that parallels maturation. B7 contributes to the T cell stimulatory function of dendritic cells, as do the other accessory molecules. B7-2 is expressed on dendritic cells and macrophages at several sites in situ, especially… CONTINUE READING
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