Expression of B-myb in neuroblastoma tumors is a poor prognostic factor independent from MYCN amplification.

@article{Raschell1999ExpressionOB,
  title={Expression of B-myb in neuroblastoma tumors is a poor prognostic factor independent from MYCN amplification.},
  author={Giuseppe Raschell{\'a} and Vincenzo Cesi and Roberto Amendola and Anna Negroni and Barbara Tanno and Pierluigi Altavista and Gian Paolo Tonini and B de Bernardi and Bruno Calabretta},
  journal={Cancer research},
  year={1999},
  volume={59 14},
  pages={3365-8}
}
The transcription factors of the Myb family are expressed in several tissues and play an important role in cell proliferation, differentiation, and survival In this study, the expression of A-myb, B-myb, and c-myb was investigated in a group of 64 neuroblastomas at different dinical stages by a sensitive reverse transcription-PCR tchnique and correlated with patients' survival. All of the myb genes were frequently expressed in neuroblastoma tumors. Interestingly, the expression of B-myb, which… CONTINUE READING

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