Expression of Angiopoietin-1 in Human Glioblastomas Regulates Tumor-Induced

  title={Expression of Angiopoietin-1 in Human Glioblastomas Regulates Tumor-Induced},
  author={Ilaria Cascone and Ilaria Zanon and Stefano Carlo Previtali and Roberto Piva},
To define a role for the angiopoietin/Tie2 system in astrocytoma angiogenesis, we examined the expression of angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) in these tumors by immunohistochemistry and in situ hybridization. Furthermore, we studied in vitro the effects elicited by glioblastoma cell–secreted Ang1 or by recombinant Ang1 on functions of endothelial cells (ECs). Our observations of astrocytomas show that a stage-specific induction of angiopoietins occurs and is correlated with… CONTINUE READING