Expression of Adipocyte/Macrophage Fatty Acid-Binding Protein in Tumor-Associated Macrophages Promotes Breast Cancer Progression.

@article{Hao2018ExpressionOA,
  title={Expression of Adipocyte/Macrophage Fatty Acid-Binding Protein in Tumor-Associated Macrophages Promotes Breast Cancer Progression.},
  author={Jiaqing Hao and Fei Yan and Yuwen Zhang and Ashley R. Triplett and Ying Zhang and Debra A. Schultz and Yanwen Sun and Jun Zeng and Kevin A. T. Silverstein and Qi Zheng and David A Bernlohr and Margot P. Cleary and Nejat K. Egilmez and Edward R Sauter and Shujun Liu and J. Timothy Suttles and Bichun Li},
  journal={Cancer research},
  year={2018},
  volume={78 9},
  pages={2343-2355}
}
Tumor-associated macrophages (TAM) play a critical role in cancer development and progression. However, the heterogeneity of TAM presents a major challenge to identify clinically relevant markers for protumor TAM. Here, we report that expression of adipocyte/macrophage fatty acid-binding protein (A-FABP) in TAM promotes breast cancer progression. Although upregulation of A-FABP was inversely associated with breast cancer survival, deficiency of A-FABP significantly reduced mammary tumor growth… CONTINUE READING
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