Expression of Activin βA and Mighty during Skeletal Muscle Atrophy

  • Leong S. M, Y. Lin
  • Published 2009

Abstract

Myostatin, a TGFβ superfamily member, is an important modulator of myogenesis. While deletion of myostatin gene results in double-muscling phenotype, over-expression of myostatin gives rise to muscle wasting. Another negative regulator of myogenesis alongside myostatin is Activin, both being the TGFβ superfamily member, share the same signaling pathway via… (More)

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