Expression of AP-2alpha, c-kit, and cleaved caspase-6 and -3 in naevi and malignant melanomas of the skin. A possible role for caspases in melanoma progression?

@article{Woenckhaus2003ExpressionOA,
  title={Expression of AP-2alpha, c-kit, and cleaved caspase-6 and -3 in naevi and malignant melanomas of the skin. A possible role for caspases in melanoma progression?},
  author={Christian Woenckhaus and Juergen Giebel and Klaus Failing and Irina Fenic and Thomas Dittberner and Micaela Poetsch},
  journal={The Journal of pathology},
  year={2003},
  volume={201 2},
  pages={
          278-87
        }
}
Progression of melanoma is associated with loss of the transcription factor AP-2alpha and tyrosine-kinase receptor c-kit. However, the mechanisms by which these two proteins are down-regulated have not been fully elucidated. Fifty non-selected melanomas comprising ten superficial spreading melanomas (five exhibiting a radial growth phase and five a vertical growth phase), ten primary nodular melanomas, 30 melanoma metastases, and 16 naevi were investigated by direct sequencing analysis of the… CONTINUE READING

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