Expression of ALDH1 in axillary lymph node metastases is a prognostic factor of poor clinical outcome in breast cancer patients with 1-3 lymph node metastases.

@article{Nogami2014ExpressionOA,
  title={Expression of ALDH1 in axillary lymph node metastases is a prognostic factor of poor clinical outcome in breast cancer patients with 1-3 lymph node metastases.},
  author={Tomohiro Nogami and Tadahiko Shien and Takehiro Tanaka and Keiko Nishiyama and Taeko Mizoo and Takayuki Iwamto and Hirokuni Ikeda and Naruto Taira and Hiroyoshi Doihara and Shinichiro Miyoshi},
  journal={Breast cancer},
  year={2014},
  volume={21 1},
  pages={58-65}
}
BACKGROUND Recently, evidence in support of the cancer stem cell (CSC) hypothesis has been accumulating. On the other hand, it has been reported that the expression of aldehyde dehydrogenase 1 (ALDH1) in primary breast cancer is a powerful predictor of a poor clinical outcome, and that breast cancer stem cells express ALDH1. According to the CSC hypothesis, development of metastases requires the dissemination of CSC that may remain dormant and be reactivated to cause tumor recurrence. In this… CONTINUE READING
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