Expression of ABC transporters in human hepatocyte carcinoma cells with cross-resistance to epirubicin and mitoxantrone.

@article{Kamiyama2006ExpressionOA,
  title={Expression of ABC transporters in human hepatocyte carcinoma cells with cross-resistance to epirubicin and mitoxantrone.},
  author={Naoya Kamiyama and Saori Takagi and Chiaki Yamamoto and Takeaki Kudo and Takahito Nakagawa and Masato Takahashi and Kazuaki Nakanishi and Hiromasa Takahashi and Satoru Todo and Ken Iseki},
  journal={Anticancer research},
  year={2006},
  volume={26 2A},
  pages={885-8}
}
BACKGROUND In order to understand the cross-resistance between epirubicin (EPI) and mitoxantrone (MIT), EPI- and MIT-resistant cells were established and their cross-resistance was evaluated. MATERIALS AND METHODS The degrees of growth inhibition of EPI-resistant HLE-EPI cells and MIT-resistant HLE-MIT cells by anticancer drugs were measured. The mRNA expressions of multidrug resistance protein 1 (MDR1)/ABCB1 and breast cancer resistance protein (BCRP)/ABCG2 were also measured by quantitative… CONTINUE READING

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