Expression of A disintegrin and metalloprotease 10 in pancreatic carcinoma.

  title={Expression of A disintegrin and metalloprotease 10 in pancreatic carcinoma.},
  author={Matthias Martin Gaida and Natascha Haag and Frank G{\"u}nther and Darjus Felix Tschaharganeh and Peter Schirmacher and Helmut Friess and Nathalia A. Giese and Jan Schmidt and Moritz Nicolas Wente},
  journal={International journal of molecular medicine},
  volume={26 2},
The protease ADAM10 influences progression and metastasis of cancer cells and is overexpressed in various malignancies. Therefore, the aim of our study was to evaluate the expression and potential function of ADAM10 in the pathophysiology of pancreatic cancer (PDAC). ADAM10 expression in normal pancreatic (NP), chronic pancreatitis (CP), PDAC tissues, as well as PDAC cell lines was determined. To evaluate whether rhADAM10 or ADAM10 silencing influences cancer cell viability, MTT assay was used… CONTINUE READING