Expression of 72 kilodalton type IV collagenase (gelatinase A) in benign and malignant ovarian tumors.

Abstract

BACKGROUND 72 Kilodalton (kd) type IV collagenase is a matrix metalloproteinase that specifically cleaves type IV collagen molecules. The enzyme has been postulated to have an important role in the invasion and spread of malignant tumors. EXPERIMENTAL DESIGN In situ hybridization was used to study the expression of the 72 kd type IV collagenase mRNA in 24… (More)

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