Expression of 25(OH)D3 24-hydroxylase in distal nephron: coordinate regulation by 1,25(OH)2D3 and cAMP or PTH.

@article{Yang1999ExpressionO2,
  title={Expression of 25(OH)D3 24-hydroxylase in distal nephron: coordinate regulation by 1,25(OH)2D3 and cAMP or PTH.},
  author={Wen Yang and P. A. Friedman and Rajiv Kumar and John L Omdahl and Brian K May and Mei-Lung Siu-Caldera and Gudimetla Satyanarayana Reddy and Stamatios Christakos},
  journal={The American journal of physiology},
  year={1999},
  volume={276 4 Pt 1},
  pages={E793-805}
}
Previous studies using microdissected nephron segments reported that the exclusive site of renal 25-hydroxyvitamin D3-24-hydroxylase (24OHase) activity is the renal proximal convoluted tubule (PCT). We now report the presence of 24OHase mRNA, protein, and activity in cells that are devoid of markers of proximal tubules but express characteristics highly specific for the distal tubule. 24OHase mRNA was undetectable in vehicle-treated mouse distal convoluted tubule (DCT) cells but was markedly… CONTINUE READING
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