Expression of 14-3-3 ζ and interaction with protein kinase C in the rat retina in early diabetes

  title={Expression of 14-3-3 ζ and interaction with protein kinase C in the rat retina in early diabetes},
  author={Yun Hong Kim and Yeong Sik Kim and Seong Su Kang and Hae Sook Noh and Hyun Jin Kim and Gyeong Jae Cho and Woo Sik Choi},
The present study aimed to investigate the expression levels of and the relationship between 14-3-3 ζ and protein kinase C (PKC) in the retina of early diabetes. Changes in the expression levels of, and interaction between, 14-3-3 ζ and PKC were investigated by Northern and Western blot analyses, immunoprecipitation and double immunostaining in the retina of diabetic rats after 6 weeks of diabetes. PKC activity was examined using a PKC assay. In the diabetic retina, the molecular levels of 14-3… CONTINUE READING

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Change of rhodopsin kinase and transducin in the rat retina at early stage of diabetes

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  • Exp Eye Res
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- induced vascular dysfunction , blocks protein kinase C - stimulated transcriptional activation through inhibition of transcription factor binding to a phorbol response element

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