Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system.

  title={Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system.},
  author={Christian M Veldman and Margherita T. Cantorna and Hector F DeLuca},
  journal={Archives of biochemistry and biophysics},
  volume={374 2},
In addition to its role in calcium and skeletal homeostasis, there is increasing evidence that the hormonal form of vitamin D, 1, 25-dihydroxyvitamin D(3), appears to serve as a modulator of the immune system. We have determined the level of the 1, 25-dihydroxyvitamin D(3) receptor (VDR) in resting and activated lymphocytes by immuno- and ligand-binding assays. As expected from previous work, the total T lymphocyte population contains VDR whose levels are increased when activated and treated… CONTINUE READING

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