Expression of γ-Glutamylcysteine Synthetase During Development

  title={Expression of γ-Glutamylcysteine Synthetase During Development},
  author={A L Levonen and Risto Lapatto and Mika Saksela and Kari O. Raivio},
  journal={Pediatric Research},
Prematurity has been associated with low glutathione (GSH) concentrations in bronchoalveolar lavage fluid as well as in leukocytes from tracheal aspirates and peripheral blood. To elucidate whether this is caused by deficient GSH synthesis, the expression and activity of γ-glutamylcysteine synthetase (glutamate-cysteine ligase, GCS, EC, the rate-limiting enzyme for GSH synthesis, were measured from fetal, neonatal, and adult human liver, lung, and kidney samples. The highest activity… CONTINUE READING


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1 Excerpt