Expression of α-defensin 1-3 in T cells from severe cutaneous drug-induced hypersensitivity reactions.

@article{Morel2011ExpressionO,
  title={Expression of α-defensin 1-3 in T cells from severe cutaneous drug-induced hypersensitivity reactions.},
  author={Esther Morel and Lorena {\'A}lvarez and Rosario Caba{\~n}as and Ana Mar{\'i}a Fiandor and Rosa D{\'i}ez D{\'i}az and Salvador Escamochero and Nieves Prior and Miguel Blanca and Teresa Bell{\'o}n},
  journal={Allergy},
  year={2011},
  volume={66 3},
  pages={360-7}
}
BACKGROUND Cytotoxic T cells seem to be the main effector cells in Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). However, recent data support a role of the innate immune system in the etiopathology of drug-induced cutaneous reactions. In this study, we analyzed the expression of α-defensins 1-3 in mononuclear cells from patients with SJS/TEN, drug-induced maculopapular exanthema (MPE), and healthy donors. METHODS DEFA1A3 gene expression was analyzed by quantitative and end… CONTINUE READING

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