Expression of ΔF508 Cystic Fibrosis Transmembrane Regulator (CFTR) Decreases Membrane Sialylation

@article{Dosanjh2009ExpressionO,
  title={Expression of ΔF508 Cystic Fibrosis Transmembrane Regulator (CFTR) Decreases Membrane Sialylation},
  author={A. Dosanjh and E. Muchmore},
  journal={The Open Respiratory Medicine Journal},
  year={2009},
  volume={3},
  pages={79 - 84}
}
Chronic colonization and infection of the lung with Pseudomonas aeruginosa is a major cause of morbidity and mortality in cystic fibrosis (CF) patients. Imundo, et al. determined that CF cells had a higher concentration of an asialoganglioside (asialo-GM1), to which both P. aeruginosa and S. aureus bound preferentially. We sought to determine if the expression of mutant CFTR is associated with altered sialylation. Our study of epithelial cells transfected with normal and mutant ΔF508 CFTR, the… Expand
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