Expression ofβ1 integrins in non-neoplastic mammary epithelium, fibroadenoma and carcinoma of the breast

@article{Mechtersheimer1993ExpressionOI,
  title={Expression ofβ1 integrins in non-neoplastic mammary epithelium, fibroadenoma and carcinoma of the breast},
  author={Gunhild Mechtersheimer and Matthias H. J. Munk and Thomas F. E. Barth and Karin Koretz and Peter L Moeller},
  journal={Virchows Archiv A},
  year={1993},
  volume={422},
  pages={203-210}
}
β1 Integrins were examined immunohisto-chemically in normal and mastopathic mammary glands, 12 benign tumours and 90 carcinomas of the breast using monoclonal antibodies againstβ1 andα1 toβ6 subunits. When compared with epithelial cells of non-neoplastic mammary glands and of benign tumours, carcinoma cells showed considerable quantitative changes in the pattern ofα2,α3 andα6 subunit expression. In contrast, the distribution pattern ofβ1,α1,α4 andα5 antigens corresponded to the situation… CONTINUE READING
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