Expression noise and acetylation profiles distinguish HDAC functions.

  title={Expression noise and acetylation profiles distinguish HDAC functions.},
  author={Leehee Weinberger and Yoav Voichek and Itay Tirosh and Gil Hornung and Ido Amit and Naama Barkai},
  journal={Molecular cell},
  volume={47 2},
Gene expression shows a significant variation (noise) between genetically identical cells. Noise depends on the gene expression process regulated by the chromatin environment. We screened for chromatin factors that modulate noise in S. cerevisiae and analyzed the results using a theoretical model that infers regulatory mechanisms from the noise versus mean relationship. Distinct activities of the Rpd3(L) and Set3 histone deacetylase complexes were predicted. Both HDACs repressed expression. Yet… CONTINUE READING
Highly Cited
This paper has 129 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.
43 Citations
56 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 43 extracted citations

129 Citations

Citations per Year
Semantic Scholar estimates that this publication has 129 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 56 references

Similar Papers

Loading similar papers…