Expression noise and acetylation profiles distinguish HDAC functions.

@article{Weinberger2012ExpressionNA,
  title={Expression noise and acetylation profiles distinguish HDAC functions.},
  author={Leehee Weinberger and Yoav Voichek and Itay Tirosh and Gil Hornung and Ido Amit and Naama Barkai},
  journal={Molecular cell},
  year={2012},
  volume={47 2},
  pages={193-202}
}
Gene expression shows a significant variation (noise) between genetically identical cells. Noise depends on the gene expression process regulated by the chromatin environment. We screened for chromatin factors that modulate noise in S. cerevisiae and analyzed the results using a theoretical model that infers regulatory mechanisms from the noise versus mean relationship. Distinct activities of the Rpd3(L) and Set3 histone deacetylase complexes were predicted. Both HDACs repressed expression. Yet… CONTINUE READING
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