Expression microarray analysis reveals genes associated with in vitro resistance to cisplatin in a cell line model

@article{Watson2007ExpressionMA,
  title={Expression microarray analysis reveals genes associated with in vitro resistance to cisplatin in a cell line model},
  author={M. B. Watson and M. Lind and L. Smith and P. Drew and L. Cawkwell},
  journal={Acta Oncologica},
  year={2007},
  volume={46},
  pages={651 - 658}
}
We aimed to investigate the mechanisms of cisplatin resistance using an in vitro cancer model. A derivative breast cancer cell line (MCF-7CR) was established which demonstrated significant resistance to cisplatin at clinically relevant low concentrations compared to the MCF-7 parental cell line. Expression microarray analysis was used to identify targets from a 3k cancer-related oligonucleotide platform which were differentially expressed between the derivative and parental cell lines. Real… Expand
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