Expression levels of insulin-like growth factor-1 and multidrug resistance-associated protein-1 indicate poor prognosis in patients with gastric cancer.

@article{Ge2009ExpressionLO,
  title={Expression levels of insulin-like growth factor-1 and multidrug resistance-associated protein-1 indicate poor prognosis in patients with gastric cancer.},
  author={Jie Ge and Zhikang Chen and Shaobin Wu and Jinxiang Chen and Xiaoli Li and Jun Li and Jiye Yin and Z H Chen},
  journal={Digestion},
  year={2009},
  volume={80 3},
  pages={
          148-58
        }
}
BACKGROUND/OBJECTIVES Insulin-like growth factor-1 receptor (IGF-1R) displays a key role in tumor transformation and metastasis. It also makes tumor cells more resistant to chemotherapy. The aim of this study was to investigate the correlation between IGF-1R and multidrug resistance-associated protein-1 (MRP-1), and the clinical significance of their expression in gastric carcinoma (GC). METHODS IGF-1R and MRP-1 expressed in 113 specimens were detected by immunohistochemistry. The correlation… CONTINUE READING

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