Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulence.

@article{Carlisle2009ExpressionLO,
  title={Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulence.},
  author={Patricia L. Carlisle and Mohua Banerjee and Anna L. Lazzell and Carlos Monteagudo and Jos{\'e} Luis L{\'o}pez-Ribot and David Kadosh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 2},
  pages={599-604}
}
Candida albicans, the major human fungal pathogen, undergoes a reversible morphological transition from single yeast cells to pseudohyphal and hyphal filaments (elongated cells attached end-to-end). Because typical C. albicans infections contain a mixture of these morphologies it has, for many years, been difficult to assess the relative contribution of each form to virulence. In addition, the regulatory mechanisms that determine growth in pseudohyphal and hyphal morphologies are largely… CONTINUE READING
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Morphogenetic signaling pathways in Candida albicans

  • AJ Brown
  • Candida and Cadidiasis, ed Calderone RA (Am Soc…
  • 2002

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