Expression levels of CD47, CD35, CD55, and CD59 on red blood cells and signal-regulatory protein-alpha,beta on monocytes from patients with warm autoimmune hemolytic anemia.

@article{Barros2009ExpressionLO,
  title={Expression levels of CD47, CD35, CD55, and CD59 on red blood cells and signal-regulatory protein-alpha,beta on monocytes from patients with warm autoimmune hemolytic anemia.},
  author={Melca Maria Oliveira Barros and Mihoko Yamamoto and Maria Stella Figueiredo and Rodolfo Delfino Cançado and Elisa Yuriko Sugano Kimura and Dante M{\'a}rio Langhi and Carlos S{\'e}rgio Chiattone and Jos{\'e} Orlando Bordin},
  journal={Transfusion},
  year={2009},
  volume={49 1},
  pages={
          154-60
        }
}
BACKGROUND Animal models have shown that CD47-deficient mice develop severe autoimmune hemolytic anemia (AIHA) because the binding of red blood cell (RBC) CD47 to signal-regulatory protein (SIRP-alpha) on macrophages contributes to the inhibition of phagocytosis. In contrast, complement-inhibitory proteins such as CD35, CD55, and CD59 may protect RBCs against the lysis by complement. STUDY DESIGN AND METHODS With the use of flow cytometric analyses, the expression of CD47, CD35, CD55, and… CONTINUE READING

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