Expression in Pichia pastoris and characterization of APETx2, a specific inhibitor of acid sensing ion channel 3.

@article{Anangi2010ExpressionIP,
  title={Expression in Pichia pastoris and characterization of APETx2, a specific inhibitor of acid sensing ion channel 3.},
  author={Raveendra Anangi and Chih-Cheng Chen and Yi-Wen Lin and Yuan-Ren Cheng and C Cheng and Yi-Chun Chen and Yuan-Ping Chu and W L Chuang},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2010},
  volume={56 8},
  pages={1388-97}
}
Acid sensing ion channels (ASICs) are family of proteins predominantly present in the central and peripheral nervous system. They are known to play important roles in the pathophysiology of pain and ischemic stroke. APETx2 is a potent and selective inhibitor of ASIC3-containing channels and was isolated from sea anemone Anthopleura elegantissima. To facilitate the study on the molecular determinants of ASIC3-ligand interactions, we expressed recombinant APETx2 in the Pichia pastoris (P… CONTINUE READING

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