Expression genetics identifies spinal mechanisms supporting formalin late phase behaviors

  title={Expression genetics identifies spinal mechanisms supporting formalin late phase behaviors},
  author={Xiangqi Li and Peyman Sahbaie and Ming Zheng and Jennifer Leigh Ritchie and Gary Peltz and Jeffrey S Mogil and John David Clark},
  booktitle={Molecular pain},
BACKGROUND Formalin injection into rodent hind paws is one of the most commonly employed pain assays. The resulting nocifensive behaviors can be divided into two phases differing in timing, duration and underlying mechanisms. Spinal sensitization has long been felt to participate in the second phase of this response, although this sensitization is incompletely understood. By using correlative analysis between spinal gene expression and mouse strain-dependent intensity of late phase behavior, we… CONTINUE READING


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