Expression from the transferrin gene promoter in transgenic mice.

  title={Expression from the transferrin gene promoter in transgenic mice.},
  author={Rejean L. Idzerda and Richard R. Behringer and M. Theisen and J I Huggenvik and G Stanley McKnight and Ralph L. Brinster},
  journal={Molecular and cellular biology},
  volume={9 11},
Transferrin is an iron-binding protein that is expressed as a major product in liver and secreted into the plasma. To study the tissue-specific regulatory regions of this gene, the genomic mouse transferrin (mTf) gene was cloned and characterized by partial sequence analysis and S1 nuclease mapping of the transcriptional start site. Fusion genes containing the transferrin gene promoter and 5'-flanking sequences were ligated to the human growth hormone (hGH) gene and used to produce transgenic… CONTINUE READING