Expression from the herpes simplex virus type 1 latency-associated promoter in the murine central nervous system.

@article{Smith2000ExpressionFT,
  title={Expression from the herpes simplex virus type 1 latency-associated promoter in the murine central nervous system.},
  author={Corey Smith and Robin H L Lachmann and Stacey Efstathiou},
  journal={The Journal of general virology},
  year={2000},
  volume={81 Pt 3},
  pages={
          649-62
        }
}
Herpes simplex virus type 1 (HSV-1) establishes latency in neurones of both the central (CNS) and peripheral nervous system and can be used to drive long-term expression of the lacZ reporter gene by insertion of an encephalomyocarditis virus IRES-linked gene 1.5 kb downstream of the latency-associated transcript (LAT) start site. However, the kinetics of LAT promoter (LAP) activity, and its ability to function in all neuronal types within the CNS has not been studied in detail. In order to… CONTINUE READING
Highly Cited
This paper has 24 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
SHOWING 1-10 OF 16 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Classical herpes latency revisited

  • P. Wildy, H. J. Field, A. A. Nash
  • In Virus Persistence Symposium
  • 1982
Highly Influential
2 Excerpts

Similar Papers

Loading similar papers…