Expression cloning of a serotonin transporter: a new way to study antidepressant drugs.

@article{Hoffman1994ExpressionCO,
  title={Expression cloning of a serotonin transporter: a new way to study antidepressant drugs.},
  author={Beth J. Hoffman},
  journal={Pharmacopsychiatry},
  year={1994},
  volume={27 1},
  pages={16-22}
}
Tricyclic antidepressants revolutionized the treatment of depression. These results and the monoamine-depleting effect of reserpine have contributed to the proposal that an imbalance in monoamines is a causal factor in depression. Most antidepressants act to concentrate monoamines in the synapse either by blocking metabolism via monoamine oxidase or by inhibiting reuptake by plasma membrane transporters. We have used a novel cDNA expression cloning strategy to isolate cDNAs for the… CONTINUE READING