Expression cloning of a rat B2 bradykinin receptor.

  title={Expression cloning of a rat B2 bradykinin receptor.},
  author={Anita McEachern and Earl R. Shelton and Sunil Bhakta and Rena Obernolte and Christian Bach and P J Zuppan and Jiro Fujisaki and Richard W. Aldrich and Kurt Jarnagin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={88 17},
A cDNA encoding a functional bradykinin receptor was isolated from a rat uterus library by a clonal selection strategy using Xenopus laevis oocytes to assay for expression of bradykinin responses. The predicted protein is homologous to the seven transmembrane G protein-coupled superfamily of receptors. Bradykinin and its analogs stimulate a Cl- current oocytes expressing the receptor with the rank order of potency: bradykinin approximately Lys-bradykinin greater than [Tyr8]-bradykinin much… CONTINUE READING


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