Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

@article{AbouSamra1992ExpressionCO,
  title={Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.},
  author={Abdul Badi Abou-Samra and Harald W Jueppner and Thomas L. Force and Mason Wright Freeman and X. F. Kong and Ernestina Schipani and Pablo Ure{\~n}a and James Richards and Joseph V. Bonventre and John T. Potts},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 7},
  pages={
          2732-6
        }
}
Parathyroid hormone (PTH), a major regulator of mineral ion metabolism, and PTH-related peptide (PTHrP), which causes hypercalcemia in some cancer patients, stimulate multiple signals (cAMP, inositol phosphates, and calcium) probably by activating common receptors in bone and kidney. Using expression cloning, we have isolated a cDNA clone encoding rat bone PTH/PTHrP receptor from rat osteosarcoma (ROS 17/2.8) cells. The rat bone PTH/PTHrP receptor is 78% identical to the opossum kidney receptor… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 226 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 124 extracted citations

Role of regulator of G protein signaling proteins in bone.

Frontiers in bioscience • 2014
View 12 Excerpts
Highly Influenced

Monocyte chemoattractant protein-1 is a mediator of the anabolic action of parathyroid hormone on bone.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2013
View 10 Excerpts
Highly Influenced

227 Citations

051015'94'99'05'11'17
Citations per Year
Semantic Scholar estimates that this publication has 227 citations based on the available data.

See our FAQ for additional information.