Expression cloning of a cocaine-and antidepressant-sensitive human noradrenaline transporter

@article{Pacholczyk1991ExpressionCO,
  title={Expression cloning of a cocaine-and antidepressant-sensitive human noradrenaline transporter},
  author={Tadeusz Pacholczyk and Randy D. Blakely and Susan G. Amara},
  journal={Nature},
  year={1991},
  volume={350},
  pages={350-354}
}
AT most synapses, chemical signalling is terminated by a rapid reaccumulation of neurotransmitter into presynaptic terminals1–5. Uptake systems for the biogenic amines are the initial site of action for therapeutic antidepressants and drugs such as cocaine and the amphetamines. We have isolated a complementary DNA clone encoding a human noradrenaline transporter. The cDNA sequence predicts a protein of 617 amino acids, with 12–13 highly hydrophobic regions compatible with membrane-spanning… 

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