Expression cloning in K+ transport defective yeast and distribution of HBP1, a new putative HMG transcriptional regulator.

@article{Lesage1994ExpressionCI,
  title={Expression cloning in K+ transport defective yeast and distribution of HBP1, a new putative HMG transcriptional regulator.},
  author={Florian Lesage and J P Hugnot and Ez Z. Amri and Paola Grimaldi and Jacques Barhanin and Michael Lazdunski},
  journal={Nucleic acids research},
  year={1994},
  volume={22 18},
  pages={3685-8}
}
The rat HBP1 cDNA was cloned by its capacity to suppress the potassium transport-defective phenotype of mutant Saccharomyces cerevisiae cells. HBP1 cDNA encodes a 513 amino acids protein which, unexpectedly, does not share any homology with K+ transporters or K+ channels. However, a search in protein databases reveals that HBP1 contains a putative DNA-binding domain called HMG-box. Northern blot analysis shows that HBP1 is expressed in a variety of tissues and that in adipocyte and myogenic… CONTINUE READING

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