Expression-cloning and sequence of a cDNA encoding human growth hormone-releasing factor

@article{Mayo1983ExpressioncloningAS,
  title={Expression-cloning and sequence of a cDNA encoding human growth hormone-releasing factor},
  author={Kelly Edward Mayo and Wylie Vale and Jean Eduard Frederic Rivier and Michael G. Rosenfeld and Ronald M Evans},
  journal={Nature},
  year={1983},
  volume={306},
  pages={86-88}
}
Growth hormone-releasing factor (GRF) is believed to mediate both neural and hormonal control of the release and perhaps synthesis of growth hormone (GH) from the anterior pituitary. Its presence in only minute quantities in the hypothalamus hampered for many years efforts to determine its structure. Recently, two groups independently characterized a peptide from two human pancreatic tumours that possessed GH-releasing activity1,2. Antibodies to this peptide have revealed immunoreactive… CONTINUE READING
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