Expression changes of CD177 and MPO as novel biomarkers in lung tissue of CLP model rats

@article{Rasooli2018ExpressionCO,
  title={Expression changes of CD177 and MPO as novel biomarkers in lung tissue of
CLP model rats},
  author={Azadeh Rasooli and Elham Ghafari and Hamed Saedi and Saba Miri},
  journal={Turkish journal of medical sciences},
  year={2018},
  volume={48 6},
  pages={
          1321
        }
}
Background/aim Sepsis is an unregulated systemic response to microbial invasion that can lead to multiple organ failure. This study aims at investigating the relationships among myeloperoxidase (MPO) and CD177 in major organ systems including whole blood, liver, and lung tissues in septic rats. Materials and methods Sepsis was induced by cecal ligation and puncture (CLP) in female Wistar rats. Whole blood, liver, and lung samples were obtained from rats of 3 groups (n = 10 for each group… 
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9 Citations
Background Citations
3
Methods Citations
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9 Citations

Citation Type

Citation Type

Comparison between MPO, CD177 and NF-κB Gene Expression of Septic Rats Treated with Mentha longifolia Essential Oils
TLDR
The results demonstrated that M. longifolia essential oil treatment could protect against sepsis-induced liver and lung injury by reducing inflammatory factor.
Comparative Effect of Three Non-Steroidal Anti-Inflammatory Drugs on Gene Expression of Myeloperoxidasein Lung and Liver Tissues of Septic Rats
TLDR
It seems that the treatment of animals with selected drugs have the inhibiting effect on the increase of MPO gene expression and results in reducing the damage to the liver and lung tissue caused by sepsis.
Data on changes of NF-κB gene expression in liver and lungs as a biomarker and hepatic injury in CLP-induced septic rats
Endogenous Sulfur Dioxide Improves the Survival Rate of Sepsis by Improving the Oxidative Stress Response during Lung Injury
TLDR
Endogenous sulfur dioxide improves the survival rate of sepsis by improving the oxidative stress response during lung injury and decreasing the number of WBCS and the percentage of PMN cells.
Transcriptome Meta-Analysis Deciphers a Dysregulation in Immune Response-Associated Gene Signatures during Sepsis
TLDR
The role of significant and widespread immune activation (IL1R2, MMP9), along with oxidative stress (ARG1) and the recruitment of neutrophils, in sepsis (ELANE, MPO) is demonstrated.
Biomarkers of sepsis: time for a reappraisal
TLDR
The number of biomarkers being identified is still increasing although at a slower rate than in the past, and the clinical role of these biomarkers needs to be better evaluated.
Fermented soybean meal extract improves oxidative stress factors in the lung of inflammation/infection animal model
TLDR
It is demonstrated that a diet containing fermented soybean meal extract improved extreme inflammatory response in an infectious disease like sepsis by reducing inflammatory factors.
Identification of a Four-Gene Signature for Diagnosing Paediatric Sepsis
TLDR
A four-gene signature composed of ANXA3, CD177, GRAMD1C, and TIGD3 effectively distinguished patients with paediatric sepsis from those in the control group and can be used as new biomarkers to distinguish patients with parenthesis from healthy individuals.
Neutrophil Phenotypes and Functions in Trauma and Trauma-Related Sepsis.
TLDR
Neutrophils and their functions are highlighted as potential future targets for optimizing post-traumatic treatment strategies, which potentially may improve patient outcomes.

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