Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells

@article{Morales2004ExpressionAT,
  title={Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells},
  author={Alejo A. Morales and Anna S B Olsson and Fredrik Celsing and Anders {\"O}sterborg and Mikael Jondal and L M Osorio},
  journal={Leukemia},
  year={2004},
  volume={18},
  pages={41-47}
}
Bmf is a BH3-only Bcl-2 family member that is normally sequestered to myosin V motors by binding to the dynein light chain 2 (DLC2). Certain damage signals release Bmf, which then binds prosurvival Bcl-2 proteins and triggers apoptosis. Here, two novel isoforms of human Bmf, Bmf-II and Bmf-III, were identified and cloned from cDNA derived from B-chronic lymphocytic leukemia (B-CLL) cells. Bmf-II and Bmf-III were characterized as two splice variants, lacking the BH3 domain but retaining the DLC2… CONTINUE READING
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