Expression and targeting to the plasma membrane of xClC-K, a chloride channel specifically expressed in distinct tubule segments of Xenopus laevis kidney.

@article{Maulet1999ExpressionAT,
  title={Expression and targeting to the plasma membrane of xClC-K, a chloride channel specifically expressed in distinct tubule segments of Xenopus laevis kidney.},
  author={Yves Maulet and R{\'e}gis C Lambert and Serge Mykita and Jerome A. Mouton and Mariagrazia Partisani and Yannick Bailly and Guy Bombarde and Anne Feltz},
  journal={The Biochemical journal},
  year={1999},
  volume={340 ( Pt 3)},
  pages={737-43}
}
ClC-K channels are Cl- channels specifically expressed in vertebrate kidneys. Although their heterologous functional expression is still controversial, indirect evidence points to them as major factors involved in Cl- reabsorption in the nephron. We cloned xClC-K, an amphibian (Xenopus) homologue of mammalian ClC-K. The cDNA encodes a 77 kDa protein presenting 62% similarity with human ClC-Kb. The protein is monoglycosylated and is expressed primarily in the Xenopus kidney. It is localized in… CONTINUE READING