Expression and subcellular localization of human AP endonuclease 1 (HAP1/Ref-1) protein: a basis for its role in human disease.

@article{Kakolyris1998ExpressionAS,
  title={Expression and subcellular localization of human AP endonuclease 1 (HAP1/Ref-1) protein: a basis for its role in human disease.},
  author={S A Kakolyris and Loukas Kaklamanis and Alexandra N Giatromanolaki and Michael J Koukourakis and Ian D. Hickson and Gil Barzilay and Helen Turley and R. Leek and Panagiotis Kanavaros and Vassilis Georgoulias and Kevin C. Gatter and Adrian L. Harris},
  journal={Histopathology},
  year={1998},
  volume={33 6},
  pages={561-9}
}
AIMS Human AP endonuclease 1 (HAP1) plays a major role in the repair of apurinic/apyrimidinic (AP) sites in cellular DNA by catalysing hydrolytic cleavage of the phosphodiester backbone 5' to the site. HAP1 is also known to be a potent reduction-oxidation (redox) factor, regulating the binding activity of a number of transcription factors. The purpose of the present study was to examine the expression of HAP-1 in a wide range of human tissues. METHODS AND RESULTS Using a recently developed… CONTINUE READING

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