Expression and structure of the human NGF receptor

  title={Expression and structure of the human NGF receptor},
  author={Dan Johnson and Anthony A. Lanahan and Charles R. Buck and A Sehgal and Claudia Morgan and Eric H. Mercer and Mark A. Bothwell and Moses V Chao},
Efficient processing and expression of human nerve growth factor receptors in Xenopus laevis oocytes: effects on maturation
Determination of the amino acid sequence by molecular cloning indicates that the NGF receptor is a cysteine-rich protein which contains a signal peptide sequence and spans the lipid bilayer with a single transmembrane sequence.


Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
The entire 1,370-amino-acid sequence of the human insulin receptor precursor is deduced from a single complementary DNA clone, finding sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close
Gene transfer and molecular cloning of the human NGF receptor.
Affinity cross-linking, metabolic labeling and immunoprecipitation, and equilibrium binding with 125I-labeled NGF revealed that this NGF receptor had the same size and binding characteristics as the receptor from human melanoma cells and rat PC12 cells.
The neu oncogene encodes an epidermal growth factor receptor-related protein
A neu complementary DNA clone isolated from a cell line transformed by this oncogene is decribed and suggests strongly that the neu gene encodes the receptor for an as yet unidentified growth factor.