Expression and stability of hypoxia inducible factor 1α in osteosarcoma.

BACKGROUND Hypoxia contributes to both physiological and pathological processes and its effects are mainly mediated through the transcription factors hypoxia-inducible factor 1α and 2α (HIF1α and HIF2α). The purpose of this study was to examine the role of these proteins in osteosarcoma progression. PROCEDURES We developed a method to isolate primary… CONTINUE READING

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