Expression and significance of HERG (KCNH2) potassium channels in the regulation of MDA-MB-435S melanoma cell proliferation and migration.

@article{Afrasiabi2010ExpressionAS,
  title={Expression and significance of HERG (KCNH2) potassium channels in the regulation of MDA-MB-435S melanoma cell proliferation and migration.},
  author={Emad Afrasiabi and Marika Hietam{\"a}ki and Tero Viitanen and Pramod Sukumaran and Nina Bergelin and Kid T{\"o}rnquist},
  journal={Cellular signalling},
  year={2010},
  volume={22 1},
  pages={57-64}
}
The human ether-a-go-go related gene (HERG) potassium channel has elicited intense scientific interest due to its role in cardiac repolarization and its association with arrhythmia and sudden cardiac death. Increasing evidence indicates the involvement of HERG channels in the pathophysiology of cancer. In the present study we investigated the expression of HERG protein in MDA-MB-435S melanoma cells, and its importance in regulating cell proliferation and migration. Our results showed that HERG… CONTINUE READING
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