Expression and role of angiotensin II type 2 receptor in the kidney and mesangial cells of spontaneously hypertensive rats.

@article{Goto2002ExpressionAR,
  title={Expression and role of angiotensin II type 2 receptor in the kidney and mesangial cells of spontaneously hypertensive rats.},
  author={Masahisa Goto and Masashi Mukoyama and Akira Sugawara and Takayoshi Suganami and Masato Kasahara and Kensei Yahata and Hisashi Makino and Shinichi Suga and Issei Tanaka and Kazuwa Nakao},
  journal={Hypertension research : official journal of the Japanese Society of Hypertension},
  year={2002},
  volume={25 1},
  pages={125-33}
}
Angiotensin II type 2 (AT2) receptor is developmentally regulated and exerts antiproliferative and proapoptotic actions. Genetic ablation of this receptor in mice affects regulation of blood pressure, but the involvement of the AT2 receptor in the pathogenesis of hypertension remains unknown. In the present study, we examined developmental changes of angiotensin receptor subtypes in the kidney of stroke-prone spontaneously hypertensive rats (SHRSP), and compared them with those in normotensive… CONTINUE READING

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