Expression and role of a2 vacuolar-ATPase (a2V) in trafficking of human neutrophil granules and exocytosis.

@article{GilmanSachs2015ExpressionAR,
  title={Expression and role of a2 vacuolar-ATPase (a2V) in trafficking of human neutrophil granules and exocytosis.},
  author={Alice Gilman-Sachs and Anjali Tikoo and Leyla Akman-Anderson and Mukesh Kumar Jaiswal and Evangelos I Ntrivalas and Kenneth D Beaman},
  journal={Journal of leukocyte biology},
  year={2015},
  volume={97 6},
  pages={
          1121-31
        }
}
Neutrophils kill microorganisms by inducing exocytosis of granules with antibacterial properties. Four isoforms of the "a" subunit of V-ATPase-a1V, a2V, a3V, and a4V-have been identified. a2V is expressed in white blood cells, that is, on the surface of monocytes or activated lymphocytes. Neutrophil associated-a2V was found on membranes of primary (azurophilic) granules and less often on secondary (specific) granules, tertiary (gelatinase granules), and secretory vesicles. However, it was not… CONTINUE READING
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