Expression and role of PML gene in normal adult hematopoiesis: functional interaction between PML and Rb proteins in erythropoiesis

@article{Labbaye1999ExpressionAR,
  title={Expression and role of PML gene in normal adult hematopoiesis: functional interaction between PML and Rb proteins in erythropoiesis},
  author={Catherine Labbaye and Mauro Valtieri and Fausto Grignani and Rossella Puglisi and Luisella Luchetti and Barbara Masella and Myriam Alcalay and Elvira Pelosi and Cesare Peschle},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={3529-3540}
}
The expression of the PML gene was investigated in purified early hematopoietic progenitor cells (HPCs) induced to unilineage erythroid or granulocytic differentiation. PML mRNA and protein, while barely detectable in quiescent HPCs, are consistently induced by growth factor stimulation through the erythroid or granulocytic lineage. Thereafter, PML is downmodulated in late granulocytic maturation, whereas it is sustainably expressed through the erythroid pathway. In functional studies, PML… CONTINUE READING

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