Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.

@article{Biers2010ExpressionAR,
  title={Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.},
  author={Charlotta B{\"o}iers and Natalija Buza-Vidas and Christina T Jensen and Cornelis J H Pronk and Shabnam Kharazi and Lilian Wittmann and Ewa Sitnicka and Anne Hultquist and Sten Eirik W Jacobsen},
  journal={Blood},
  year={2010},
  volume={115 24},
  pages={5061-8}
}
Mice deficient in c-fms-like tyrosine kinase 3 (FLT3) signaling have reductions in early multipotent and lymphoid progenitors, whereas no evident myeloid phenotype has been reported. However, activating mutations of Flt3 are among the most common genetic events in acute myeloid leukemia and mice harboring internal tandem duplications within Flt3 (Flt3-ITD) develop myeloproliferative disease, with characteristic expansion of granulocyte-monocyte (GM) progenitors (GMP), possibly compatible with… CONTINUE READING