Expression and replication of the hepatitis B virus genome under foreign promoter control.

@article{Junker1987ExpressionAR,
  title={Expression and replication of the hepatitis B virus genome under foreign promoter control.},
  author={M Junker and Peter R. Galle and Heinz Schaller},
  journal={Nucleic acids research},
  year={1987},
  volume={15 24},
  pages={10117-32}
}
A novel expression system was established that allows expression and propagation of the human hepatitis B virus (HBV) genome in cultured animal cells. An overlength HBV genome encoding the viral pregenomic RNA was put under transcriptional control of the human metallothionein IIA promoter thereby replacing the endogenous HBV core gene promoter. Transient expression of this construct in hepatoma cells resulted in formation of particles indistinguishable from HBV (Dane particles). Uncoupling of… CONTINUE READING

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